Comments
yourfanat wrote: I am using another tool for Oracle developers - dbForge Studio for Oracle. This IDE has lots of usefull features, among them: oracle designer, code competion and formatter, query builder, debugger, profiler, erxport/import, reports and many others. The latest version supports Oracle 12C. More information here.
Cloud Expo on Google News

2008 West
DIAMOND SPONSOR:
Data Direct
SOA, WOA and Cloud Computing: The New Frontier for Data Services
PLATINUM SPONSORS:
Red Hat
The Opening of Virtualization
GOLD SPONSORS:
Appsense
User Environment Management – The Third Layer of the Desktop
Cordys
Cloud Computing for Business Agility
EMC
CMIS: A Multi-Vendor Proposal for a Service-Based Content Management Interoperability Standard
Freedom OSS
Practical SOA” Max Yankelevich
Intel
Architecting an Enterprise Service Router (ESR) – A Cost-Effective Way to Scale SOA Across the Enterprise
Sensedia
Return on Assests: Bringing Visibility to your SOA Strategy
Symantec
Managing Hybrid Endpoint Environments
VMWare
Game-Changing Technology for Enterprise Clouds and Applications
Click For 2008 West
Event Webcasts

2008 West
PLATINUM SPONSORS:
Appcelerator
Get ‘Rich’ Quick: Rapid Prototyping for RIA with ZERO Server Code
Keynote Systems
Designing for and Managing Performance in the New Frontier of Rich Internet Applications
GOLD SPONSORS:
ICEsoft
How Can AJAX Improve Homeland Security?
Isomorphic
Beyond Widgets: What a RIA Platform Should Offer
Oracle
REAs: Rich Enterprise Applications
Click For 2008 Event Webcasts
SYS-CON.TV
Top Links You Must Click On


Researchers Discover Gender-based Differences in Alzheimer's Disease

CHICAGO, Nov. 26, 2012 /PRNewswire-USNewswire/ -- All patients with Alzheimer's disease (AD) lose brain cells, which leads to a shrinking, or atrophy, of the brain. But the pattern of gray matter loss is significantly different in men and women, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).

"We found that the extent and distribution of regional gray matter volume loss in the brain was strongly influenced by gender," said lead researcher Maria Vittoria Spampinato, M.D., associate professor of radiology at the Medical University of South Carolina in Charleston.

According to the Alzheimer's Association, 5.4 million Americans have AD, the sixth-leading cause of death in the U.S. Currently, there is no cure for AD, which lends urgency to research efforts designed to better understand, diagnose and treat this devastating illness.

"There is a strong interest in using magnetic resonance imaging (MRI) to assess brain atrophy with the purpose of monitoring dementia progression noninvasively and to aid in understanding which factors can influence brain atrophy progression and distribution in the Alzheimer's brain," Dr. Spampinato said.

In the study, Dr. Spampinato and colleagues analyzed data on 109 patients, including 60 men and 49 women (mean age 77), who participated in the Alzheimer's Disease Neuroimaging Initiative (ADNI), a major study that followed hundreds of cognitively healthy individuals and individuals with mild cognitive impairment (MCI) and AD over a period of five years.

During the five-year period, each of the 109 patients progressed from amnestic MCI (in which the patient suffers memory loss but maintains cognitive function) to AD. Using MR images of the patients' brains taken when they were diagnosed with AD and 12 months before and after the diagnosis, the researchers created brain maps that illustrated gray matter changes.

The brain maps revealed that compared to male patients, the women had greater atrophy in gray matter 12 months prior to their AD diagnosis and at the time of their diagnosis. The brain maps also showed that the men and women in the study lost gray matter volume in different areas of the brain as their disease progressed from MCI to AD.

"The female patients in our study initially had more gray matter atrophy than the male patients but over time, the men caught up," Dr. Spampinato said. "In the men, the disease developed more aggressively in a shorter period of time."

Dr. Spampinato said the gender differences in atrophy patterns have important implications for the development of therapies for MCI and AD.

"These differences should be taken into consideration when testing new drugs in clinical trials," she said. "Knowing the difference between the male and female patterns of atrophy will help researchers better decipher a patient's response to drug therapy."

Coauthors are Zoran Rumboldt, M.D., Markus Weininger, M.D., Vavro Hrvoje, M.D., Karen Patrick, M.D., and Ryan O'Neal Parker, Ph.D. 

Note: Copies of RSNA 2012 news releases and electronic images will be available online at RSNA.org/press12 beginning Monday, Nov. 26.

RSNA is an association of more than 50,000 radiologists, radiation oncologists, medical physicists and related scientists, promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)

Editor's note: The data in these releases may differ from those in the published abstract and those actually presented at the meeting, as researchers continue to update their data right up until the meeting. To ensure you are using the most up-to-date information, please call the RSNA Newsroom at 1-312-949-3233.

For patient-friendly information on MRI of the brain, visit RadiologyInfo.org.

AT A GLANCE

  • Researchers using MRI have found that Alzheimer's disease causes a different pattern of brain volume loss in men, compared to women.
  • Women with AD initially show greater brain atrophy, but the disease progresses more quickly in men.
  • Approximately 5.4 million Americans have AD.

SOURCE Radiological Society of North America (RSNA)

About PR Newswire
Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Enterprise Open Source Magazine Latest Stories . . .
IBM’s Blue Box Cloud, powered by OpenStack, is now available in any of IBM’s globally integrated cloud data centers running SoftLayer infrastructure. Less than 90 days after its acquisition of Blue Box, IBM has integrated its Blue Box Cloud Dedicated private-cloud-as-a-service into it...
Puppet Labs has announced the next major update to its flagship product: Puppet Enterprise 2015.2. This release includes new features providing DevOps teams with clarity, simplicity and additional management capabilities, including an all-new user interface, an interactive graph for vi...
I was experimenting with Java HashSet, which is a pretty expensive collection to create, but it has a benefit of the O(1) performance on the retrieval of elements from this collection. Based on my experiments performance of HashSet is improved over the last year. I’ve written a small ...
When I started exploring virtualization, like many folks, I was in awe of how much efficiency came with moving physical servers into VMs. To this day, the number of success stories about improved usage, reduced overhead costs and increased functionality makes virtualization a solid bus...
XebiaLabs has announced that XL Deploy, its Application Release Automation software, has received certification of its integration with ServiceNow. With XL Deploy from XebiaLabs, ServiceNow users can now easily automate the application deployment process so releases can occur in a re...
All enterprises, be they large or small, national or multinational, commercial or government agency, American or Chinese, Japanese or European, are carrying the dead weight of their history and almost certainly continuing to add unnecessary complexity and excessive cost that will progr...
Subscribe to the World's Most Powerful Newsletters
Subscribe to Our Rss Feeds & Get Your SYS-CON News Live!
Click to Add our RSS Feeds to the Service of Your Choice:
Google Reader or Homepage Add to My Yahoo! Subscribe with Bloglines Subscribe in NewsGator Online
myFeedster Add to My AOL Subscribe in Rojo Add 'Hugg' to Newsburst from CNET News.com Kinja Digest View Additional SYS-CON Feeds
Publish Your Article! Please send it to editorial(at)sys-con.com!

Advertise on this site! Contact advertising(at)sys-con.com! 201 802-3021




SYS-CON Featured Whitepapers
ADS BY GOOGLE